Extracellular matrix (ECM) hydrogel as submucosal fluid pad

• Main Authors: NARANJO GUTIERREZ JUAN DIEGO, SALADIN LINDSEY TAMIKO, BADYLAK STEPHEN FRANCIS
• Format: Patent
• Language: Chinese; English
• Published: 20.12.2022
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

Disclosed are methods for exfoliating mucosa and submucosa from an innate muscular layer of an organ region of a subject, wherein the organ is not an esophagus. In some embodiments, the organ is in the gastrointestinal tract. These methods include submucosal injection of a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel into an organ of a subject to form a pad between a submucosal layer and a lower intrinsic muscle layer of a region of the organ wherein the ECM hydrogel has the following features: a) a time of up to 50% gelation at a temperature of about 37 DEG C of less than 30 minutes; b) a flow viscosity suitable for infusion to the organ; and c) a stiffness of about 10 to about 400 Pascals (Pa). 公开了用于从受试者的器官区域的固有肌层中剥离粘膜和粘膜下层的方法，其中器官不是食管。在一些实施方案中，器官在胃肠道中。这些方法包括将包含细胞外基质(ECM)水凝胶的药物组合物粘膜下注射到受试者的器官中，以在器官区域的粘膜下层和下层固有肌层之间形成垫，其中ECM水凝胶具有以下特征：a)在约37℃的温度下达到50％凝胶化的时间少于30分钟；b)适于输注到器官的流动粘度；和c)约10至约400帕斯卡(Pa)的刚度。