Method of forming particles by continuous droplet formation and dehydration

• Main Authors: BROWN PETER, LIU LEI, KHAWAJA, MUHAMMAD, VARTAK SACHIN, COFFMAN CHRISTOPHER S, IVEY, JOHN, W, CARTER TYLER LEE, SHADBAR SHAHRAM, HEBERT, PAUL, F, ORR JAMES G
• Format: Patent
• Language: Chinese; English
• Published: 16.12.2022
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

The present disclosure relates to methods that enable continuous droplet formation and droplet dehydration to provide pharmaceutically related particles useful in therapy. In particular, the methods disclosed herein allow for controlled continuous droplet formation and dehydration to produce rounded particles with low internal void spaces comprising bioactive therapeutic biologics. 本公开涉及能够实现连续液滴形成和液滴脱水以提供可用于治疗的药学上相关的颗粒的方法。特别地，本文公开的方法允许受控的连续液滴形成和脱水以产生包含生物活性治疗性生物制剂的具有低内部空隙空间的圆形颗粒。