P-chiral alpha-hydroxyl (ester) phosphate ester compound and preparation method thereof

The invention discloses a P-chiral alpha-hydroxyl (ester) phosphate compound and a preparation method thereof, and belongs to the field of organic chemistry. The compound comprises a formula I-1 and a formula I-2, the structural general formula of the compound is shown as the formula I-1 and the for...

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Bibliographic Details
Main Authors PEI CHENGXIN, GAO RUNLI, HU HUIJUAN, WANG HONGMEI
Format Patent
LanguageChinese
English
Published 13.12.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:The invention discloses a P-chiral alpha-hydroxyl (ester) phosphate compound and a preparation method thereof, and belongs to the field of organic chemistry. The compound comprises a formula I-1 and a formula I-2, the structural general formula of the compound is shown as the formula I-1 and the formula I-2, and under the catalytic action of commercial porcine pancreatic lipase PPL, a racemic compound in the formula I-1 is subjected to bioconversion through kinetic resolution, and the optically pure P-chiral alpha-hydroxyl (ester) phosphate compound is efficiently and highly selectively obtained. The use amount of the porcine pancreatic lipase can be adjusted according to the use amount of a substrate; a reaction system is a vinyl acetate solution (acyl donor). The method has the characteristics of simplicity and convenience in operation, high reaction efficiency, mild reaction conditions, high enantioselectivity, easiness in product separation and high product purity, and has a very good application prospect
Bibliography:Application Number: CN202211016949