Medicinal gliquidone crystal form and preparation method thereof

• Main Authors: ZHANG WEIWEI, LEE JEONG-EUI, ZHAO YUWEN, LI WEI, WANG HUALI, YAN BAOMING, ZHANG HAIBO, LU JUMING
• Format: Patent
• Language: Chinese; English
• Published: 13.12.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a gliquidone medicinal crystal form and a preparation method thereof, and belongs to the technical field of medicines. An X-ray powder diffraction spectrum represented by an angle of 2 [theta] has characteristic peaks at the positions of 10.52 to 10.92, 13.85 to 14.25, 15.13 to 15.53, 16.43 to 16.83, 17.42 to 17.82, 18.40 to 18.80, 18.90 to 19.30, 20.15 to 20.55, 21.36 to 21.76, 23.14 to 23.54 and 25.28 to 25.68. The melting point of the gliquidone medicinal crystal form I is 178 to 182 DEG C. The prepared gliquidone crystal form I is high in purity, the purity can reach 99.0% or above and completely reaches the medicinal level, and the preparation method is simple, practical, stable and suitable for industrial production. The gliquidone crystal form I has an obvious hypoglycemic effect and can be used for preparing hypoglycemic drugs. 本发明涉及一种格列喹酮药用晶型及其制备方法，属于医药技术领域。以2θ角度表示的X-射线粉末衍射光谱在10.52-10.92，13.85-14.25，15.13-15.53，16.43-16.83，17.42-17.82，18.40-18.80，18.90-19.30，20.15-20.55，21.36