Oral paclitaxel nanoparticles modified by cholic acid as well as preparation method and application of oral paclitaxel nanoparticles

• Main Authors: KO JONG-HO, LIU WEI, CHEN LIQING, HUANG WEI, KIM MYEONG-HEE
• Format: Patent
• Language: Chinese; English
• Published: 13.12.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of pharmaceutical preparations, discloses oral paclitaxel nanoparticles modified by cholic acid as well as a preparation method and application of the oral paclitaxel nanoparticles modified by the cholic acid, and particularly relates to the oral paclitaxel nanoparticles modified by the cholic acid, the oral paclitaxel nanoparticles modified by the cholic acid comprise total lipid, a chitosan-glycocholic acid polymer and glucose, the total lipid comprises a paclitaxel cholesterol compound, phospholipid, cholesterol, phospholipid-polyethylene glycol and a phospholipid-polyethylene glycol-quercetin polymer; the weight ratio of paclitaxel to cholesterol in the paclitaxel cholesterol compound is (1: 0.1)-(1: 1). The cholic acid modified oral paclitaxel nanoparticles are combined with an ASBT transporter overexpressed at the ileum tail end through surface modified cholic acid, so that the transintestinal transport efficiency of drugs is remarkably improved, and the purposes of im