Composition for preventing or treating lung disease comprising hyaluronic acid and proteoglycan connexin 1

• Main Authors: JANG JI-MIN, PIAO YONGWEI, ZHOU DAN, PARK BOKYUNG, KIM DAE-KYUNG, YUN SO-YOON
• Format: Patent
• Language: Chinese; English
• Published: 02.12.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

Relates to a recombinant hyaluronic acid and proteoglycan linked protein 1 (hyaluronan and proteoglycan link protein 1), and a preparation method of the recombinant hyaluronic acid and proteoglycan linked protein 1 (hyaluronan and proteoglycan link protein 1). The present invention relates to a composition for preventing or treating lung diseases, which comprises, as an active ingredient, at least one selected from the group consisting of a HAPLN1 (hyaluronic acid and proteoglycan connexin 1) protein, a gene encoding the HAPLN1 protein, and an effective agent that promotes the expression of the HAPLN1 protein or gene or activates the function thereof, and a composition for preventing or treating lung diseases. The recombinant HAPLN1 protein according to the present disclosure has an excellent effect of improving alveolar injury caused by aging or elastin reduction, and thus can effectively prevent or treat lung diseases such as chronic bronchitis, asthma, emphysema, and chronic obstructive lung diseases. 涉及一种