Safe and effective methods of treating ulcerative colitis with anti-IL12/IL23 antibodies

The present invention describes methods and compositions for providing clinically proven safe and effective treatment of ulcerative colitis, particularly moderate to severe active ulcerative colitis, for patients with insufficient response or poor tolerance to conventional or existing therapies by i...

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Main Authors LEE KANGHO, ZHANG HONG, MARANO CARMELO, JOHNS JEFFREY, ADDOKUN, OZCAN, STRAUSS RAIMUND, SHIELDS-TUTTLE KEVIN, O 'BRIEN CAROLYN
Format Patent
LanguageChinese
English
Published 02.12.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention describes methods and compositions for providing clinically proven safe and effective treatment of ulcerative colitis, particularly moderate to severe active ulcerative colitis, for patients with insufficient response or poor tolerance to conventional or existing therapies by intravenous and/or subcutaneous administration of an anti-IL-12/IL-23p40 antibody. 本发明描述了用于通过静脉内和/或皮下施用抗IL-12/IL-23p40抗体，为对常规疗法或现有疗法应答不足或耐受不良的患者提供对溃疡性结肠炎特别是中度至重度活动性溃疡性结肠炎的临床证实安全且有效的治疗的方法和组合物。
Bibliography:Application Number: CN202180028613