Application of nicotinamide mononucleotide in product for preventing dyszoospermia of obese males

• Main Authors: ZHANG ZHOUXIN, TAN YONGPENG, ZHOU LEGUANG, LI MEIXIANG, LEI XIAOCAN, WANG JINYUAN, LIU KE, ZHANG SHUN, CHEN XI
• Format: Patent
• Language: Chinese; English
• Published: 02.12.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of nicotinamide mononucleotide in a product for preventing obese male dyszoospermia. The product is a product for preventing obese male dyszoospermia. The invention provides a new application of NMN in improvement of obese mouse testis dyszoospermia, and provides a new treatment strategy and a drug target for human intervention and control of obesity induced testis dyszoospermia and improvement of obese male fertility. The weight, fat weight and serum lipid metabolism hormone level of obese mice can be obviously reduced by supplementing NMN to the obese mice. After the NMN is supplemented to obese mice, the forms of testis and epididymis and the diameter and area of seminiferous tubules can be improved, and the sperm quantity, sperm motility and sperm quality can be improved. After NMN is supplemented to obese mice, the morphology and function of supporting cells are remarkably improved. The NMN is supplemented for obese mice, and the spermatogenic dysfunction can be improv