Preparation method and application of degradable suture line based on polyelectrolyte method

• Main Authors: ZHU XIU'AN, WANG RUMENG, DENG CHAO, WANG YURAN, ZHANG JUE, HSIEH HSIN-YUN
• Format: Patent
• Language: Chinese; English
• Published: 29.11.2022
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention discloses a preparation method and application of a degradable suture line based on a polyelectrolyte method, and the preparation method comprises the following steps: S100, jointly dropwise adding a chitosan solution and a sodium alginate solution to a hydrophobic surface, and attaching the two liquids to form an interface; s200, pulling out the polyelectrolyte on the interface to form a continuous interface reaction so as to prepare fibers; s300, enabling the fibers to sequentially pass through a cross-linking agent, sterile water and an ethanol solution, so as to prepare the degradable suture line, and an antibacterial and anti-inflammatory suture line. The bi-crosslinking structure fiber is obtained through ionic crosslinking, the preparation method is simple and mild, and no drug residue exists; the suture line can be endowed with various properties, so that the suture line can be matched with various application scenes. 本发明公开了一种基于聚电解质法的可降解缝合线的制备方法及其应用，包括如下步骤：S100、将壳聚糖溶液与海藻酸钠溶液共同滴加至疏水性表面，两种