Reduction of PIEZO2-mediated pain by nacrenic acid

• Main Authors: CORDERO MORALES JULIO FRANCISCO, ROMERO LUIS OCTAVIO, KOCHAT, HARRY, ZHI KAINING, VALERIA VASQUET, CASLEY ALEXANDER THEODORE
• Format: Patent
• Language: Chinese; English
• Published: 25.11.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described herein is a method of treating pain by administering a pharmaceutical composition comprising a therapeutically effective amount of pearl acid to a subject in need thereof. Also described are pharmaceutical compositions (e.g., topical and transdermal compositions) comprising pearl acid and a pharmaceutically acceptable excipient. Further described is a composition for the treatment of pain comprising nacrenic acid, eicosapentaenoic acid, and a pharmaceutically acceptable excipient. 本文描述了一种通过向需要治疗疼痛的受试者施用包含治疗有效量的珍珠酸的药物组合物来治疗疼痛的方法。还描述了药物组合物(如局部和经皮组合物)，其包含珍珠酸和药学上可接受的赋形剂。进一步描述了一种用于治疗疼痛的组合物，其包含珍珠酸、二十碳五烯酸和药学上可接受的赋形剂。