Peptidomimetic derivative, preparation method and application

• Main Author: LIU CHUNHE
• Format: Patent
• Language: Chinese; English
• Published: 25.11.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a peptidomimetic derivative or a salt thereof, the chemical structural formula of the compound is as shown in formula (I), and the derivative is a tautomer, a stereoisomer, a solvate, a salt of the solvate, a metabolite, a metabolic precursor or a prodrug, a pharmaceutically acceptable salt or a mixture thereof of the compound, the stereoisomer, the solvate, the salt of the solvate, the metabolite, the metabolic precursor or the prodrug and the pharmaceutically acceptable salt. The peptidomimetic derivative or the salt of the peptidomimetic derivative can effectively inhibit 3C-like cysteine protease, and can be prepared into medicines for treating and/or preventing H1N1, SARS-CoV, MERS-CoV or SARS-CoV-2 virus infection diseases. 本发明公开了一种拟肽类衍生物或其盐，所述化合物的化学结构式如式(I)所示，所述衍生物为所述化合物的互变异构体、立体异构体、溶剂化物、溶剂化物的盐、代谢产物、代谢前体或前药、药学上可接受的盐或它们的混合物。本发明的拟肽类衍生物或其盐可有效抑制3C样半胱氨酸蛋白酶，可制备为治疗和/或预防H1N1、SARS-CoV、MERS-CoV或SARS-CoV-2病毒感染疾病的药物。