Application of artemisia annua extract in preparation of stem cell apoptosis inhibitor

• Main Authors: ZHOU WENSHU, ZHENG WENHUA, LIN RUOHONG
• Format: Patent
• Language: Chinese; English
• Published: 25.11.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses an application of arteannuin in preparation of a mesenchymal stem cell apoptosis inhibitor. Rat bone marrow mesenchymal stem cells are used as representatives as experimental subjects, hydrogen peroxide is used for simulating and inducing mesenchymal stem cell injury, research finds that the artemisia annua extract has a protective effect in hydrogen peroxide induced cell injury, and the protective effect mechanism of the artemisia annua extract is preliminarily discussed. The result shows that the artemisia annua extract plays a protective role by inhibiting up-regulation of p-erk and p-p38 expression caused by H2O2 and activating a PI3K/AKT pathway. The Artemisia annua extract can be used as a protective drug for mesenchymal stem cells for preventing and treating stem cell apoptosis. 本发明公开了黄花蒿素在制备间充质干细胞凋亡抑制剂中的应用。本发明以大鼠骨髓间充质干细胞为代表作为实验对象，以过氧化氢摸拟诱导间充质干细胞损伤，研究发现黄花蒿提取物在过氧化氢诱导的细胞损伤中具有保护作用，并初步探讨了黄花蒿提取物的保护作用机制，结果说明黄花蒿提取物通过抑制H2O2引起的p-erk和p-p38表达的上调和激活PI3K/AKT通路发挥保护作用。黄花蒿提取物可作为间充质干细胞的保护药用于预防和治