Treatment of physiological iron overload

• Main Authors: PAPWORTH JAMES L, WECK MICHAEL, SERRE ISABELLE, GAMASHEVSKY, VLADIMIR, MENARD, DELPHINE
• Format: Patent
• Language: Chinese; English
• Published: 22.11.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An antibody to protein lyase 2 (MTP-2) is provided. Inhibition of MTP-2 reduces uptake of dietary iron and reduces release of iron from in vivo cell reservoirs. Inhibitors of MTP-2, such as antibodies against the serine protease domain, can be used to treat iron overload, which is a feature of diseases such as beta-thalassemia and which would otherwise lead to toxic accumulation of iron. The MTP-2 inhibitor in combination with an activin receptor ligand trap or with erythropoietin provides additional therapeutic effects. 提供了针对蛋白裂解酶-2(MTP-2)的抗体。抑制MTP-2减少膳食铁的摄取并减少铁从体内细胞储库中的释放。MTP-2的抑制剂(如针对丝氨酸蛋白酶结构域的抗体)可用于治疗铁过载，铁过载是诸如β-地中海贫血等疾病的特征，且原本会导致铁的毒性累积。MTP-2抑制剂与激活素受体配体陷阱或与促红细胞生成素的组合提供了额外的治疗效果。