CD28 single domain antibodies and multivalent and multispecific constructs thereof

• Main Authors: TIMMER JOHN C, WILLIS KATELYN M, CAPLAN MARK D, JACKSON, RICHARD, H, ECKELMAN BRENDAN P, KARGO, WILLIAM, S
• Format: Patent
• Language: Chinese; English
• Published: 22.11.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are binding polypeptides that specifically bind to CD28. More specifically, provided herein are fusion proteins comprising multivalent and/or multispecific constructs that bind to at least CD28. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors thereof, and methods of use and uses of the provided CD28 binding polypeptides for the treatment of diseases and disorders, such as cancer. 本文提供了特异性结合CD28的结合多肽。更具体地，本文提供了融合蛋白，其包括至少结合CD28的多价和/或多特异性构建体。还提供了含有所述多肽的药物组合物，编码所述多肽的核酸分子及其载体，以及所提供的CD28结合多肽用于治疗疾病和病症如癌症的使用方法和用途。