Deformable, developable and high-drug-loading emulsion droplet embolism microsphere based on Janus particles and preparation method of deformable, developable and high-drug-loading emulsion droplet embolism microsphere
The invention discloses a deformable, developable and high-drug-loading emulsion droplet embolization microsphere based on Janus particles and a preparation method thereof. Amphiphilic Janus particles are used as a stabilizer, in an iodized oil and chemotherapeutic drug system, water-in-oil or oil-i...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
22.11.2022
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a deformable, developable and high-drug-loading emulsion droplet embolization microsphere based on Janus particles and a preparation method thereof. Amphiphilic Janus particles are used as a stabilizer, in an iodized oil and chemotherapeutic drug system, water-in-oil or oil-in-water emulsion droplet embolization microspheres are obtained through shear emulsification, and the particle size is 10-1000 microns. The drug carrier has high drug loading capacity and excellent slow release characteristic, and can effectively improve local drug concentration of tumors and reduce side effects caused by burst release of drugs. The emulsion droplet microsphere also has good dispersibility and stability, has good passing ability in a microcatheter during an interventional operation and is not easy to block the catheter, and a single emulsion droplet microsphere can be distinguished by naked eyes under X-ray fluoroscopy in an embolization operation. The emulsion droplet microsphere also has good vis |
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Bibliography: | Application Number: CN202210813975 |