Mutant genes related to gallbladder cancer and application of mutant genes

• Main Authors: SONG FENGLIANG, ZHANG KECHENG, ZHANG BAOHUA, LI LIANG, YANG PINGHUA
• Format: Patent
• Language: Chinese; English
• Published: 11.11.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides a group of mutant genes related to gallbladder cancer and application thereof. The mutant gene related to the gallbladder carcinoma comprises one or more of TP53, ABCC4, AMPD1, ACHE, OXCT1, AGL, BRCA1, MEMO1, WNK1 and ALDH1L1. The mutant gene related to the gallbladder carcinoma comprises one or more of TP53, ABCC4, AMPD1, ACHE, OXCT1, AGL, BRCA1, MEMO1, WNK1 and ALDH1L1. Whole exon sequencing (WES) is carried out through an established early generation human tumor xenotransplantation (PDX) model and primary tumor tissue, gallbladder cancer related mutant genes including TP53, ABCC4, AMPD1, ACHE, OXCT1, AGL, BRCA1, MEMO1, WNK1 and ALDH1L1 and mutation types are screened and identified, the gallbladder cancer related mutant genes can be used as potential action targets for gallbladder cancer treatment, a basis is provided for preparation of drugs for treating gallbladder cancer, and meanwhile, the gallbladder cancer related mutant genes can be used for preparing drugs for treating gallbl