Hydrogel with SOD (superoxide dismutase) simulation sites as well as preparation method and application of hydrogel

• Main Authors: LI WEILONG, GUO CHUAN, YANG QINGKUN, KONG QINGQUAN, WU YE, WANG YU, WU JINRONG
• Format: Patent
• Language: Chinese; English
• Published: 11.11.2022
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; WORKING-UP

The invention belongs to the technical field of medicines, and particularly relates to hydrogel with SOD (superoxide dismutase) simulation sites as well as a preparation method and application of the hydrogel. The hydrogel disclosed by the invention is obtained by reacting hydrogel prepared from a raw material composition in a solution containing Cu < 2 + >, and the raw material composition is prepared from the following components in parts by weight: 0.5 to 1.5 parts of carbon quantum dots, 30 to 60 parts of histidine grafted chitosan and 50 to 150 parts of oxidized hyaluronic acid. The raw material composition can also comprise ZIF-8 loaded with tanshinol. The hydrogel disclosed by the invention has good anti-infection and ROS (Reactive Oxygen Species) removal capabilities, and has a very good wound repairing effect. The hydrogel disclosed by the invention can release anti-infection components by utilizing an acidic microenvironment generated by wound infection, so that the SOD simulation site is more suita