Sustained-release microsphere preparation as well as preparation method and application thereof

• Main Authors: XU LI, HUANG PEIWEN, CAI TINGWEI, WANG XIAOGANG, HE ZHOUYANG, CHEN SANMEI, YUAN MINZHENG, ZHOU LINBO
• Format: Patent
• Language: Chinese; English
• Published: 11.11.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a sustained-release microsphere preparation. The sustained-release microsphere preparation is prepared from the following raw materials in parts by mass: 0.5-45 parts of BU08028 and 55-99.5 parts of polyester. The intrinsic viscosity of the polyester is 0.05 to 2.00 dL/g. The invention belongs to the technical field of pharmaceutical preparations, and provides a sustained-release microsphere preparation of BU08028 for the first time, which is smooth and round in surface, uniform in particle size distribution, capable of realizing long-acting sustained release, capable of realizing stable release of the sustained-release preparation, good in safety, capable of reducing the dosing frequency and beneficial to improving the medication feeling of a patient. 本发明提供一种缓释微球制剂，包括如下制备原料及其质量份数：BU080280.5-45份、聚酯55-99.5份；所述聚酯的特性粘度为0.05-2.00dL/g。本发明属于药物制剂技术领域，本发明率先提供了BU08028的缓释微球制剂，表面光滑圆整，粒径分布均匀，能够长效缓释，实现缓释制剂的平稳释放，安全性好，可减少投药次数，利于改善病患的用药感受。