Application of polydopamine-coated hemoglobin oxygen carrier in preparation of drug for promoting wound healing

• Main Authors: LI BINGTING, ZHAO LIAN, YOU GUOXING, WANG QUAN, MA NING
• Format: Patent
• Language: Chinese; English
• Published: 08.11.2022
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of a polydopamine-coated hemoglobin oxygen carrier in preparation of a drug for promoting wound healing. The polydopamine-coated hemoglobin oxygen carrier is a nano microcapsule obtained by coating hemoglobin with polydopamine. The polydopamine-coated hemoglobin oxygen carrier is used as a wound dressing to directly cover a wound, the polydopamine-coated hemoglobin oxygen carrier is suitable for treatment of various acute and chronic wounds, and the wound healing area in unit time is remarkably increased, namely, the polydopamine-coated hemoglobin oxygen carrier can improve the wound healing speed and is beneficial to wound healing, and the wound healing effect is improved. And the wound healing time can be shortened. 本发明公开聚多巴胺包裹血红蛋白氧载体在制备促创面愈合药物中的应用，所述聚多巴胺包裹血红蛋白氧载体是由聚多巴胺包裹血红蛋白得到的纳米微囊。本发明将该聚多巴胺包裹血红蛋白氧载体用作创面敷料直接覆于创面上，适用于多种急、慢性创面的治疗，单位时间内创面愈合的面积显著增加，即：聚多巴胺包裹血红蛋白氧载体可提高创面愈合的速度，有利于创面的愈合，还能缩短创面愈合的时间。