Quinoline ring-containing 1, 2, 4-oxadiazole substituted benzamide compound as well as preparation method and application thereof

• Main Authors: WANG YINGYING, TAN CHENGXIA, YANG SEN, MEI YUPENG, ZHOU YI, SUN BINLONG, HUA YI
• Format: Patent
• Language: Chinese; English
• Published: 04.11.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention belongs to the technical field of chemical synthesis and medicine application, and particularly relates to a quinoline ring-containing 1, 2, 4-oxadiazole substituted benzamide compound as well as a preparation method and application thereof. The preparation method comprises the following steps: synthesizing 2-methyl-4-hydroxyquinoline from aniline and ethyl acetoacetate, carrying out cyclization, hydrolysis and condensation on chloroacetyl chloride and amidoxime to obtain an intermediate 5-(chloromethyl)-1, 2, 4-oxadiazole substituted benzamide, and carrying out etherification reaction on the intermediate 5-(chloromethyl)-1, 2, 4-oxadiazole substituted benzamide to generate a target compound containing a quinoline ring, namely the 1, 2, 4-oxadiazole substituted benzamide compound. The preparation method is simple and convenient to operate, the structure of the obtained product is confirmed through a nuclear magnetic hydrogen spectrum, a nuclear magnetic carbon spectrum and high resolution, the o