Marker for predicting radiotherapy curative effect of local advanced esophageal squamous carcinoma, application of marker and kit

• Main Authors: GAO LINRUI, XIAO ZEFEN, LIU MEI
• Format: Patent
• Language: Chinese; English
• Published: 01.11.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses a marker for predicting the radiotherapy curative effect of local advanced esophageal squamous carcinoma, application of the marker and a kit. The marker comprises miR-143-3p and miR-223-3p. The dynamic expression level of the marker for predicting the curative effect of local advanced esophageal squamous cell carcinoma radiotherapy is related to prognosis of esophageal cancer patients after radiotherapy, can be used as a peripheral blood dynamic monitoring index in esophageal cancer radiotherapy, and provides a basis for miR-143-3p and miR-223-3p to become effective biological markers and potential therapeutic targets for curative effect prediction. The individualized treatment of the clinical local advanced esophageal squamous cell carcinoma is guided. And the combined prediction accuracy of the miR-143-3p and the miR-223-3p is 82.5 percent. 本发明公开了一种用于局部晚期食管鳞癌放疗疗效预测的标志物及其应用与试剂盒，所述标志物包括miR-143-3p和miR-223-3p。本发明中用于局部晚期食管鳞癌放疗疗效预测的标志物的动态表达水平与食管癌患者接受放疗后的预后相关，可作为食管癌放疗中外周血动态监测指标，为miR-143-3p