Febuxostat osmotic pump sustained release tablet and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to a febuxostat osmotic pump sustained release tablet and a preparation method thereof. The febuxostat osmotic pump sustained release tablet comprises a tablet core and a coating layer coated on the surface of the ta...

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Bibliographic Details
Main Authors SUN SHENGHUA, GUAN YUEQIN, WANG XIULAN
Format Patent
LanguageChinese
English
Published 01.11.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention belongs to the technical field of medicines, and particularly relates to a febuxostat osmotic pump sustained release tablet and a preparation method thereof. The febuxostat osmotic pump sustained release tablet comprises a tablet core and a coating layer coated on the surface of the tablet core, wherein the tablet core comprises the following raw material components: 50 parts of febuxostat, 60-120 parts of a diluent, 5-20 parts of an adhesive, 15-35 parts of an osmotic pressure accelerant, 15-35 parts of a pH regulator, 2-20 parts of a disintegrating agent and 1-4 parts of a lubricant; the coating layer comprises the following raw material components in parts by weight: 2-10 parts of a film-forming material, 8-16 parts of a pore-foaming agent and 20-40 parts of a plasticizer. According to the Febuxostat osmotic pump sustained release tablet, through the synergistic effect of all the raw material components, the solubility of Febuxostat in water is increased, the fluctuation amplitude of a curve
Bibliography:Application Number: CN202210799362