Application of cannabidiol in development of medicine for treating triple-negative breast cancer

• Main Authors: ZHANG ZUNYUE, GUO JUDING, BA HONGPING, YANG JIQING, WANG HUAWEI, WANG KUNHUA
• Format: Patent
• Language: Chinese; English
• Published: 28.10.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of cannabidiol in development of a medicine for treating triple-negative breast cancer, Cannabidiol (CBD) is one of cannabis extracts, is cannabinoid without any mental activity, and has a treatment effect on epilepsy, tumor, inflammation and pain after being combined with a corresponding receptor and activating a downstream pathway after entering a body; in addition, research finds that through combination of chemotherapy and CBD treatment, CBD can increase the sensitivity of breast cancer to chemotherapy drugs; the cannabidiol activates CDKN3/P53/P21/P16 signal channels in the triple-negative breast cancer cells by increasing the sensitivity of the triple-negative breast cancer cells to chemotherapeutic drugs, so that the effects of inhibiting proliferation and invasion of the triple-negative breast cancer cells and promoting cell apoptosis can be achieved. 本发明公开了大麻二酚在治疗三阴型乳腺癌药物研制中的应用，大麻二酚(Cannabidiol,CBD)是大麻提取物之一，它是一种没有任何精神活性的大麻素，CBD进入机体后，与相应受体结合，激活下游通路，对癫痫、肿瘤、炎症和疼痛均具