Polysubstituted benzene immunomodulatory compound, composition and application of polysubstituted benzene immunomodulatory compound and composition

The invention discloses a polysubstituted benzene immunomodulatory compound, a composition and application thereof. The polysubstituted benzene immunomodulatory compound has a structure as shown in a general formula (I). Experiments prove that the compound disclosed by the invention shows very stron...

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Bibliographic Details
Main Authors LIU XINGGUO, HU MIAO, WU YIZHE, ZHOU XINGLU
Format Patent
LanguageChinese
English
Published 25.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a polysubstituted benzene immunomodulatory compound, a composition and application thereof. The polysubstituted benzene immunomodulatory compound has a structure as shown in a general formula (I). Experiments prove that the compound disclosed by the invention shows very strong PD-1/PD-L1 blocking activity and can reverse T cell functions inhibited by PD-L1 at the same time. Meanwhile, the compound provided by the invention can activate an NFAT signal channel caused by PD-1/PD-L1 combination, can be absorbed by oral administration, and has good pharmacokinetic properties. Therefore, the compounds of the present invention can be used in the treatment of diseases, disorders or conditions that benefit from the inhibition of PD1 or PD-L1 activity, including infectious diseases, immune diseases, inflammatory diseases and cancers, alone or in combination with other drugs. 本发明公开了一种多取代苯类免疫调节化合物、组合物及其应用，具有通式(I)所示的结构。本发明发明人通过实验证实，本发明化合物表现出很强的PD-1/PD-L1阻断活性，同时能够逆转PD-L1抑制的T细胞功能。同时，本发明化合物能激活PD-1/PD-
Bibliography:Application Number: CN202210523081