Method for efficiently preparing oxazolidinone derivative

The invention discloses a method for efficiently preparing an oxazolidinone derivative, which comprises the following steps: by taking primary amine, methyl chloroacetate and propargyl alcohol as raw materials, synthesizing a 4-methylene oxazolidinone derivative by a one-pot method under the action...

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Bibliographic Details
Main Authors LI YANAN, LENG JING, RYU SEUL-KYOUNG, HUANG HAO, QIAO DONGMING
Format Patent
LanguageChinese
English
Published 21.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for efficiently preparing an oxazolidinone derivative, which comprises the following steps: by taking primary amine, methyl chloroacetate and propargyl alcohol as raw materials, synthesizing a 4-methylene oxazolidinone derivative by a one-pot method under the action of a metal catalyst and alkali, and then converting an exocyclic double bond into an intracyclic double bond under the catalysis of Lewis acid to obtain the oxazolidinone derivative. The route has the advantages of easily available raw materials, mild reaction conditions, simplicity and convenience in operation, atom economy and the like. 本发明公开了一种高效制备噁唑烷酮衍生物的方法，以伯胺、氯乙酸甲酯和炔丙醇为原料，在金属催化剂和碱作用下，一锅法合成4-亚甲基噁唑烷酮衍生物，随后在路易斯酸催化下，环外双键转变为环内双键，得到噁唑烷酮衍生物。本发明路线具有原料易得，反应条件温和，操作简便，原子经济等优点。
Bibliography:Application Number: CN202210989756