Method for detecting circulating BMP10 (bone morphogenetic protein 10)

• Main Authors: KARL JOHANN, SHILLINGHAUS, LUC, LOONEY VICTOR, MASON, JOHN, M., T., A, JURKNISCHKE, UWE, MALE TIM, KASTNER PETER, ENGEL ANDREAS, GREGG MICHAEL, ZIEGLER ALEXANDER, WIENHUES-THELEN URSULA-HENRIKE, SHOTTON URI, LATINI, ROBERTO
• Format: Patent
• Language: Chinese; English
• Published: 14.10.2022
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

The present invention relates to a method for assessing atrial fibrillation in a subject, the method comprising the steps of determining the amount of BMP10 in a sample from the subject, and comparing the amount of BMP10 to a reference amount, thereby assessing atrial fibrillation. Furthermore, the present invention relates to a method for diagnosing heart failure based on the determination of BMP10 in a sample from a subject. In addition, the present invention relates to a method for predicting the risk of hospitalization of a subject due to heart failure based on the determination of BMP10-type peptide in a sample from the subject. The present invention further relates to antibodies that bind to one or more BMP10 type peptides, such as NT-proBMP10. 本发明涉及一种用于评定受试者的心房颤动的方法，所述方法包括以下步骤：在来自所述受试者的样品中确定BMP10的量，以及将BMP10的所述量与参考量进行比较，由此评定心房颤动。此外，本发明涉及一种用于基于对来自受试者的样品中BMP10的确定来诊断心力衰竭的方法。另外，本发明涉及一种用于基于对来自受试者的样品中BMP10-型肽的确定来预测受试者因心力衰竭而住院的风险的方法。本发明进一步关于与一种或多种BMP10-型肽例如NT-proBMP10结合的抗体。