Synthesis of 6-bromo-cycloicaritin chroman 3, 4-diketone derivative and anti-tumor application of 6-bromo-cycloicaritin chroman 3, 4-diketone derivative

The invention relates to synthesis of a 6-bromo-cycloicaritin chroman 3, 4-diketone derivative and an anti-tumor application of the derivative. The invention discloses a 6-bromo-cycloicaritin chroman 3, 4-diketone derivative with a structural formula as shown in a formula I. R is selected from alken...

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Bibliographic Details
Main Authors ZHAO CHANGKUO, WANG XIANHENG, CUI HANQI
Format Patent
LanguageChinese
English
Published 14.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to synthesis of a 6-bromo-cycloicaritin chroman 3, 4-diketone derivative and an anti-tumor application of the derivative. The invention discloses a 6-bromo-cycloicaritin chroman 3, 4-diketone derivative with a structural formula as shown in a formula I. R is selected from alkenyl, alkynyl, alicyclic group and substituted or unsubstituted benzyl, and the designed and synthesized 6-bromo-cycloicaritin chroman 3, 4-diketone derivative as shown in the formula I is prepared by taking cycloicaritin as an initial raw material through a one-pot method, and preparing the 6-bromo-cycloicaritin chroman 3, 4-diketone derivative with the structural formula as shown in the formula I. The invention further discloses a preparation method of the 6-bromo-cycloicaritin chroman 3, 4-diketone derivative with the structural formula as shown in the formula I. Under the action of a suitable brominating reagent, various suitable alcohols react for a certain time at a suitable reaction temperature, the compound i
Bibliography:Application Number: CN202211001247