Methods for treating or preventing asthma by administering IL-4R antagonist

• Main Authors: AMIN, NEELAM, HARRER STEFAN, GRAHAM NEIL, STAUDINGER HARALD, TEPER ARIEL
• Format: Patent
• Language: Chinese; English
• Published: 11.10.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are methods for treating or preventing asthma (e.g., allergic asthma, asthma associated with allergic bronchial pulmonary aspergillosis (ABPA), moderate to severe asthma, persistent asthma, etc.) and related conditions (e.g., ABPA, an ABPA co-disease with asthma, an ABPA co-disease with cystic fibrosis (CF), an ABPA co-disease with asthma and CF) in a subject. Provided are methods comprising administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or an antigen-binding fragment thereof. 提供了用于治疗或预防受试者中的哮喘(例如，过敏性哮喘、与过敏性支气管肺曲霉病(ABPA)相关的哮喘、中度至重度哮喘、持续性哮喘等)以及相关病症(例如，ABPA、具有哮喘的ABPA共病、具有囊性纤维化(CF)的ABPA共病、具有哮喘和CF的ABPA共病)的方法。提供了包括向有需要的受试者施用治疗性组合物的方法，所述治疗性组合物包含白介素-4受体(IL-4R)拮抗剂，如抗IL-4R抗体或其抗原结合片段。