Method for direct amination of C-3 site of indole compound

The invention relates to a method for direct amination of a C-3 site of an indole compound, in particular to a method for simply, conveniently and efficiently realizing amination of the C-3 site of the indole compound under the condition that a trace amount of Lewis acid is used as a catalyst. A ser...

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Bibliographic Details
Main Authors LIAO LIHUA, LAN WEIQIAO
Format Patent
LanguageChinese
English
Published 11.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for direct amination of a C-3 site of an indole compound, in particular to a method for simply, conveniently and efficiently realizing amination of the C-3 site of the indole compound under the condition that a trace amount of Lewis acid is used as a catalyst. A series of methods for constructing C-N bonds on the C-3 site of indole reported before are mostly limited to the problems of complex raw materials, harsh reaction conditions, tedious synthesis steps, poor product results, low product yield and the like, and the methods for directly constructing the C-N bonds on the C-3 site of indole are rarely reported. The method provided by the invention overcomes some defects shown in the existing C-N bond construction method, realizes the progress of mild reaction conditions, simple operation, high product yield and easy separation and purification, and also has good practicability in the aspect of amplified preparation through experimental verification, thereby being suitable fo
Bibliography:Application Number: CN202210834735