Lactobacillus fermentum strain and composition for preventing or treating metabolic disease containing same

• Main Authors: YANG BO-KI, KANG CHANG-HO, ZHANG MINGHAO, BAEK NAM-SOO
• Format: Patent
• Language: Chinese; English
• Published: 30.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The present invention relates to a novel Lactobacillus fermentum strain (preservation number KCTC 14106BP) and a composition for preventing or treating metabolic diseases comprising the same. The lactobacillus fermentum can inhibit fat accumulation in white adipose tissues and increase anti-inflammatory cells, and can effectively inhibit fat accumulation in brown adipose tissues and liver tissues. The lactobacillus fermentum strain shows an excellent hypoglycemic effect, especially can reduce fasting blood glucose level, and can effectively improve insulin resistance by improving glucose tolerance and increasing insulin sensitivity. Therefore, the Lactobacillus fermentum strain can be usefully used for preventing or treating metabolic diseases such as obesity. 本发明涉及一种新型发酵乳杆菌菌株(保藏号KCTC 14106BP)和包含该菌株的用于预防或治疗代谢疾病的组合物。本发明的发酵乳杆菌可以在白色脂肪组织中抑制脂肪堆积并增加抗炎细胞，并且可以有效抑制棕色脂肪组织和肝组织中的脂肪堆积。发酵乳杆菌菌株表现出优异的降血糖作用，特别是可以降低空腹血糖水平，并且可通过改善葡萄糖耐量和增加胰岛素敏感性来有效改善胰岛素抵抗。因此，该发酵乳杆菌菌株可有用地用于预防或治疗代谢疾病如肥胖。