Anti-tumor antigen nano antibody and nucleic acid coding sequence and application thereof

• Main Authors: HUANG SHIWEI, CHEN MEIZHI, QIU SHAOZHI, LIN YUQUAN, PAN ZHIMING, CHEN YE, ZHOU DEYANG
• Format: Patent
• Language: Chinese; English
• Published: 30.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides an anti-tumor antigen nano antibody, which is specifically combined with a human leukocyte antigen-G. The invention also provides a nucleic acid coding sequence of the anti-tumor antigen nano antibody, an application of the anti-tumor antigen nano antibody in treating cancer and immune related diseases, and a method for detecting the HLA-G expression amount. 本发明提供一种抗-肿瘤抗原奈米抗体，其与一人类白血球抗原-G专一性结合。本发明亦提供该抗-肿瘤抗原奈米抗体的核酸编码序列、该抗-肿瘤抗原奈米抗体用于治疗癌症及免疫相关疾病的用途，及用于检测HLA-G表现量的方法。