Fluorescent reagent for detecting dimethyl chlorophosphate and preparation method thereof

• Main Authors: HU LEILEI, LIU XIAOQIAN, HUA YUWEI, ZHANG CHUCHU
• Format: Patent
• Language: Chinese; English
• Published: 30.09.2022
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; TESTING

The invention belongs to the field of chemical analysis and testing, and particularly relates to a fluorescent reagent for detecting dimethyl chlorophosphate and a preparation method of the fluorescent reagent. The fluorescent reagent is a coumarin compound based on a 5-aminoquinoline derivative as a target spot. The target part takes 5-aminoquinoline as a raw material, the 5-aminoquinoline and chloroacetyl chloride are subjected to an acylation reaction and then substituted with N-Boc-1, 4-phenylenediamine, and Boc is removed to obtain the target part; the final compound is prepared from a fluorescent dye 7-(diethylamino) coumarin-3-formic acid and a target part under the alkaline condition of N, N-diisopropylethylamine and under the catalysis of 1H-benzotriazole-1-oxytripyrrolidinyl hexafluorophosphate. The fluorescent reagent disclosed by the invention has good water solubility and excellent optical performance, and can be used for carrying out fluorescent response recognition detection on dimethyl chlorop