Optically resolved trolox intermediates and methods of making same

• Main Authors: KURODA KIICHI, SAWAMURA KIYOTO, TSUYUMINE SHINJIRO
• Format: Patent
• Language: Chinese; English
• Published: 16.09.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method for the chiral resolution of Trolox is provided. The present disclosure relates to a method of making a solid salt of a compound of formula I comprising adding an amide-based solvent to a sample comprising a compound of formula I and speculatively comprising a compound of formula II in the presence of an optical resolving agent: Formula I: (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to as R-Trolox) Formula II: (S)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to as R-Trolox, the present invention relates to 1, 3, 4, 5, 8-tetramethylchroman-2-formic acid (hereinafter referred to as S-Trolox). 提供用于Trolox的手性拆分的方法。本公开涉及制造式I的化合物的固体盐的方法，其包括向包含式I的化合物、且推测包含式II的化合物的试样中在光学拆分剂的存在下添加酰胺系溶剂：式I：(R)-6-羟基-2,5,7,8-四甲基色满-2-甲酸(以下称为R-Trolox)式II：(S)-6-羟基-2,5,7,8-四甲基色满-2-甲酸(以下称为S-Trolox)。