Modified antibacterial peptide and application thereof

• Main Authors: WANG YIPENG, WANG XU, HAO WEIJING, OUYANG JIANHONG
• Format: Patent
• Language: Chinese; English
• Published: 13.09.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a modified antibacterial peptide and application thereof, the modified antibacterial peptide is obtained by modifying an antibacterial peptide with an amino acid sequence as shown in SEQ ID NO.1, and the amino acid sequence is as shown in SEQ ID NO.2. The modified antibacterial peptide disclosed by the invention has broad-spectrum and efficient antibacterial activity, extremely strong anti-inflammatory activity and anti-biofilm activity, has a synergistic antibacterial effect with traditional antibiotics, and has the beneficial characteristics of small molecular weight, simple structure, low hemolytic activity, high stability, simple preparation method and the like; the method has huge potential application prospects in preparation of anti-inflammatory agents and antibacterial agents and in the downstream fields of preservatives, animal feed additives, cosmetic additives and the like. 本发明涉及一种改造体抗菌肽及其应用，该改造体抗菌肽通过将氨基酸序列如SEQ ID NO.1所示的抗菌肽进行改造得到，氨基酸序列如SEQ ID NO.2所示。本发明的改造体抗菌肽具有广谱高效的抗菌活性、极