Synthetic method and application of organic aluminum hydrogen reagent

• Main Authors: STEPHAN DOUGLAS WADE, TAN JINGJIE, WU YILE
• Format: Patent
• Language: Chinese; English
• Published: 13.09.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a synthesis method and application of an organic aluminum hydrogen reagent, and the synthesis method comprises the following steps: dissolving an organic aluminum chloride compound containing a strong electron-withdrawing substituent group in an organic solvent in an inert gas atmosphere, adding a metal hydride at-78 DEG C to-20 DEG C, continuously stirring for 0.5-1 hour, then heating to 10-50 DEG C, continuously reacting for 12-72 hours, and cooling to room temperature to obtain the organic aluminum hydrogen reagent. Filtering and recrystallizing to obtain an organic aluminum hydrogen reagent containing a strong electron-withdrawing substituent group; according to the invention, the metal hydride is used as a reducing agent, and meanwhile, the synthesis of the organic aluminum hydrogen reagent containing a strong electron-withdrawing substituent group is realized by controlling reaction conditions, so that high yield and high purity can be obtained, and the yield can be up to 62%; me