Biological material containing CD56 + subcellular population source exosome and preparation method thereof

• Main Authors: SUN YI, LYU HONGBIN, XU YAN, LIU QUANBO, HU JIANZHONG
• Format: Patent
• Language: Chinese; English
• Published: 13.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention belongs to the field of biomedical materials, and particularly relates to a biological material containing a CD56 + subcellular population source exosome and a preparation method of the biological material. Comprising methacrylic anhydride gelatin, a spinal cord acellular matrix and an exosome, the exosome is derived from a cell subset with a CD56 < + > marker; the exosome expresses semaphore 7A. Proteins expressed by the exosome and used for promoting nerve axon regeneration are various, the exosome is high in activity and has semaphorin 7A protein, and the effects of rapidly promoting nerve axon regeneration and inducing nerve axon regeneration can be achieved by activating integrin/MAPK signal channels; the natural spinal cord acellular matrix component can simulate the tissue microenvironment of the spinal cord, and has good tissue compatibility and extremely low immunological rejection; the sustained-release exosome retains biological activity, can play a therapeutic role brought by stem ce