Antibody for resisting novel coronavirus or antigen binding fragment thereof, kit and application

• Main Authors: ZHAO YIKUN, LI HUDAN, FU KANG, HU JUN'AN
• Format: Patent
• Language: Chinese; English
• Published: 09.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention discloses an antibody for resisting novel coronavirus or an antigen binding fragment thereof, a kit and application, and relates to the high and new technical field of biological medicine. The antibody with a specific heavy chain variable region and a specific light chain variable region or an antigen binding fragment thereof can be specifically bound with N protein of novel coronavirus (SARS-CoV-2) and has relatively high affinity, and the antibody has relatively high sensitivity and specificity on the N protein of the novel coronavirus; according to the invention, more antibody selections with better performance are provided for the detection of the novel coronavirus. 本发明公开了一种抗新型冠状病毒的抗体或其抗原结合片段、试剂盒及应用，涉及生物医药高新技术领域。具有特定重链可变区和轻链可变区的抗体或其抗原结合片段能够特异性结合新型冠状病毒(SARS-CoV-2)的N蛋白，且具有较高的亲和力，该抗体针对型冠状病毒的N蛋白具有较高的灵敏度和特异性，本发明为新型冠状病毒的检测提供了更多以及性能更优的抗体选择。