Non-classical antibacterial activity application of benzene olefin nitro compound as quorum sensing inhibitor

• Main Authors: LIU DANRUI, WANG JIANG, TANG SHI, YANG LIANGYI, JIA AIQUN
• Format: Patent
• Language: Chinese; English
• Published: 09.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a non-classical antibacterial activity application of a benzene olefin nitro compound as a quorum sensing inhibitor, and the benzene olefin nitro compound can be used as the quorum sensing inhibitor of bacillus violaceus, pseudomonas aeruginosa and serratia marcescens. Wherein the maximum inhibition rate of the p-methylstyrene nitro compound on the serratia marcescens can reach 80%, the damage rate of the p-methylstyrene nitro compound on the serratia marcescens is up to 85%, the damage rate of the p-methylstyrene nitro compound on the pseudomonas aeruginosa is up to 60%, and the p-methylstyrene nitro compound has good quorum sensing non-classical antibacterial potential application value. 本发明公开了一种苯烯烃硝基类化合物作为群体感应抑制剂的非经典抗菌活性用途，所述苯烯烃硝基类化合物可应用作为紫色杆菌、铜绿假单胞菌和粘质沙雷氏菌的群体感应抑制剂，其中对甲基苯乙烯硝基化合物对粘质沙雷氏菌的被膜抑制率最高可达80%，进一步对粘质沙雷氏菌的被膜破坏率高达85%，对铜绿假单胞菌的被膜破坏高达60%，具有很好的群体感应非经典抗菌的潜在应用价值。