Application of squalene in preparation of medicine for treating renal ischemia-reperfusion injury

• Main Authors: ZHANG WANGNING, ZHANG KAIYU, TIAN JIANGWEI
• Format: Patent
• Language: Chinese; English
• Published: 09.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of squalene in a medicine for treating acute kidney injury. Acute kidney injury is kidney injury caused by oxygen deficit and reoxygenation or acute kidney injury induced by kidney ischemia reperfusion. Squalene is used on a cell in-vitro model for intervention treatment, and it is verified that squalene improves damage of hypoxia and oxygen enrichment to renal tubular epithelial cells; the squalene is used for performing intervention treatment on a mouse in-vivo model, and biochemical indexes, pathological sections, Doppler and laser speckle are utilized for verifying that the squalene improves the acute kidney injury induced by kidney ischemia reperfusion in multiple dimensions; the squalene can inhibit kidney injury caused by hypoxia reoxygenation, and has a good effect of preventing and treating hypoxia-induced renal ischemia reperfusion. 本发明公开了所述的角鲨烯在治疗急性肾损伤药物中的应用。急性肾损伤为缺氧复氧产生的肾损伤或肾脏缺血再灌注诱导的急性肾损伤。通过在细胞体外模型上使用角鲨烯进行干预治疗，验证角鲨烯改善缺氧富氧对肾小管上皮细胞的损伤；在小鼠体内模型上使用角鲨烯进行干预治疗，利用生化指