Fluid transfer devices with integrated flow-based assays and methods of use thereof

• Main Authors: BULLINGTON GREGORY J, GAW SHAN E, GOLDBAUM, PAUL, MIAZGA JAY M, GEIRIG DANIEL
• Format: Patent
• Language: Chinese; English
• Published: 06.09.2022
• Subjects: DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; SURGERY; TESTING

A system includes a fluid transfer device and a lateral flow assay device. The fluid transfer device has an inlet fluidly coupleable with a source of bodily fluid, an outlet fluidly coupleable with a sample reservoir, and an isolation chamber configured to receive an initial volume of bodily fluid. The fluid transfer device is transitionable between (1) a first state in which the isolation chamber is in fluid communication with the inlet to receive an initial volume, (2) a second state in which the outlet is in fluid communication with the inlet to receive a subsequent flow of bodily fluid, and (3) a third state in which the isolation chamber is in fluid communication with the inlet to receive a subsequent flow of bodily fluid. A lateral flow assay device is in fluid communication with the isolated chamber to receive a portion of the initial volume of bodily fluid. The lateral flow assay device is configured to provide an indication associated with the presence of a target analyte in a bodily fluid. 一种系统包括流体传