HIV-1 GP41 neutralizing antibodies and uses thereof

• Main Authors: CHUANG GWO-YU, SHAPIRO LAWRENCE, KWONG PETER, BENDER MICHAEL, MAKSOU LU, JOUNI, BAILER ROBERT, CARLTON, KENNETH, GEORGIEV IVELIN, O'DELL SIDNEY, LAOUT MOHAMED, PEGU AMARENDRA, COOPER JEREMY, ASOKAN MANIKANDAN, CONNORS MARK, KUELTZO LISA, ZHANG BAOSHAN, MCKEE KRISTINA, SCHWARTZ RICHARD, GINDIN TAMIR, KWON YOUNG DO, OFEK GILAD
• Format: Patent
• Language: Chinese; English
• Published: 06.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention discloses neutralizing antibodies and antigen binding fragments of these antibodies that specifically bind to HIV-1Env. Nucleic acids, vectors and host cells encoding these antibodies are also provided. Methods of detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragments, nucleic acids and vectors to prevent and/or treat HIV-1 infection is disclosed. 本发明公开了特异结合HIV-1Env的中和抗体和这些抗体的抗原结合片段。还提供了编码这些抗体的核酸、载体和宿主细胞。公开了采用这些抗体检测HIV-1的方法。另外，公开了这些抗体、抗原结合片段、核酸和载体防止和/或治疗HIV-1感染的用途。