Application of metformin in preparation of medicine for preventing and/or treating lung-type oxygen poisoning

• Main Authors: WANG NAN, LIU SHULIN, FANG YIQUN, XU JI, MA JUN, BAO XIAOCHEN
• Format: Patent
• Language: Chinese; English
• Published: 06.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicine preparation, and particularly relates to application of metformin in preparation of a medicine for preventing pulmonary oxygen poisoning caused by high partial pressure oxygen, the metformin remarkably reduces lung tissue bleeding and alveolar structure damage caused by the high partial pressure oxygen, and pulmonary edema is reduced; the preparation method comprises the following steps: regulating and controlling inflammation-related reaction pathways such as P38/38MAPK, p-JAK1, p-STAT3 and the like; the lung inflammation is relieved; oxidative stress damage caused by high-pressure oxygen is reduced by reducing oxidative stress products; and the apoptosis proportion of the bronchial endothelial cells is reduced by regulating and controlling the c-myc, caspase-3 and bcl-2 pathways. Therefore, the lung injury caused by lung-type oxygen poisoning is relieved. 本发明属于医药制备领域，特别涉及二甲双胍在制备预防高分压氧导致的肺型氧中毒的药物中的应用，二甲双胍显著降低高分压氧导致的肺组织出血、肺泡结构破坏，降低肺水肿；通过调控P38/38MAPK、p-JAK1，p-STAT