Methods and compositions for treating cancer

• Main Authors: RUIZ SEBASTIEN, FARINA CHRISTOPHER J, LIANG, BO, C
• Format: Patent
• Language: Chinese; English
• Published: 02.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides compositions and methods for treating cancer in a subject by administering to the subject an antibody or fragment thereof that binds to an oxidized LDL. In some embodiments, the compositions and methods may reduce the size of the tumor, reduce macrophage infiltration, and/or inhibit metastasis. 本发明提供了通过向受试者施用与氧化LDL结合的抗体或其片段来治疗所述受试者的癌症的组合物和方法。在一些实施方案中，所述组合物和方法可减小所述肿瘤的大小，减少巨噬细胞浸润和/或抑制转移。