Methods of treating and/or preventing major adverse cardiovascular event (MACE) with combination of BET bromodomain inhibitor and dipeptidyl peptidase 4 inhibitor

• Main Authors: HALLIDAY CHRISTOPHER ROSS ARMSTRONG, LEBIODA KENNETH EUGENE, KHAN AWAZ NADEEM
• Format: Patent
• Language: Chinese; English
• Published: 02.09.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described herein are methods for treating and/or preventing a major adverse cardiovascular event (MACE) by administering to a subject in need thereof a combination of a dipeptidyl peptidase 4 (DPP-4) inhibitor and a compound of formula (I), wherein the variables of formula (I) are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or hydrate thereof. 本文描述了用于通过向有需要的个体施用二肽基肽酶4(DPP-4)抑制剂和式(I)化合物或其立体异构体、互变异构体、药学上可接受的盐或水合物的组合来治疗和/或预防主要不良心血管事件(MACE)的方法，其中式(I)的变量如本文所定义。