中介体复合物亚基抑制剂及其应用

• Format: Patent
• Language: Chinese
• Published: 05.12.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

本公开涉及促进造血干细胞或血液祖细胞分化为红细胞或其前体细胞的方法，所述方法包括使所述造血干细胞或血液祖细胞与抑制中介体复合物的尾部亚基的表达和/或活性的抑制剂接触的步骤。本公开还涉及抑制中介体复合物的尾部亚基的表达和/或活性的抑制剂在制备用于治疗受试者中与造血功能异常相关的疾病的药物中的用途，以及检测中介体复合物的尾部亚基的表达和/或活性的试剂在制备用于对受试者中与造血功能异常相关的疾病进行诊断或预后的试剂盒中的用途。 The present disclosure relates to a method of promoting the differentiation of hematopoietic stem cells or blood progenitor cells into red blood cells or precursor cells thereof, comprising the step of contacting said hematopoietic stem cells or blood progenitor cells with an inhibitor that inhibits the expression and/or activity of the tail subunit of a mediator complex. The disclosure also relates to the use of an inhibitor that inhibits the expression and/or activity of the tail subunit of the mediator complex in the preparation of a medicament for the treatment of a disease associated with hematopoietic dysfunction in a subject, the invention further discloses application of a reagent for detecting expression and/or activity of the tail subunit of the mediator compound in preparation of a kit for