Hyaluronic acid derivative composition, pharmaceutical composition, and hyaluronic acid derivative-drug conjugate composition

• Main Authors: YANG SO-YEON, KATSUMATA TORU, YABUUCHI KOHEI, FUKUMOTO KEISUKE, NAKAGAWA YOSHIYUKI
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2022
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention provides: a hyaluronic acid derivative composition; a pharmaceutical composition containing the hyaluronic acid derivative composition as a carrier; and in the hyaluronic acid derivative composition, (A) a hyaluronic acid derivative-drug-bound composition in which one or more drugs are bound to a hyaluronic acid derivative; the hyaluronic acid derivative composition contains (A) a hyaluronic acid derivative into which a steroid group is introduced and (B) a polar group-containing compound having at least one functional group selected from the group consisting of a hydroxyl group, a carboxyl group, an amino group, an amide group, a urethane group, a urea group and a mercapto group, wherein the introduction rate of the steroid group with respect to the hyaluronic acid derivative (A) is 0.1% or more but less than 35%. 本发明提供一种透明质酸衍生物组合物、含有该透明质酸衍生物组合物作为载体的药物组合物，以及该透明质酸衍生物组合物中的(A)透明质酸衍生物结合有一个以上的药物的透明质酸衍生物-药物结合组合物；所述透明质酸衍生物组合物含有(A)引入有甾基的透明质酸衍生物和(B)具有选自羟基、羧基、氨基、酰胺基、氨基甲酸酯基、脲基和巯基中的至少一种的官能团的含极性基团化合