GABAA positive allosteric modulator compound, preparation method and application thereof

• Main Authors: LI ZHENG, NING YUXI, HUBBS JED, HE YUNLIANG, LIU XIANGLEI, TOTZKE, MATTHEW
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Described herein are polymorphic forms comprising 2 ', 6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo [1, 2-b] [1, 2, 4] triazin-7-yl] biphenyl-2-formonitrile (TPA023B) or a salt thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with ph...