GABAA positive allosteric modulator compound, preparation method and application thereof

Described herein are polymorphic forms comprising 2 ', 6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo [1, 2-b] [1, 2, 4] triazin-7-yl] biphenyl-2-formonitrile (TPA023B) or a salt thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with ph...

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Bibliographic Details
Main Authors LI ZHENG, NING YUXI, HUBBS JED, HE YUNLIANG, LIU XIANGLEI, TOTZKE, MATTHEW
Format Patent
LanguageChinese
English
Published 30.08.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Described herein are polymorphic forms comprising 2 ', 6-difluoro-5'-[3-(1-hydroxy-1-methylethyl)-imidazo [1, 2-b] [1, 2, 4] triazin-7-yl] biphenyl-2-formonitrile (TPA023B) or a salt thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. In another aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with sulfuric acid. Methods of making and methods of using the same are also described herein. 本文描述了包含2',6-二氟-5'-[3-(1-羟基-1-甲基乙基)-咪唑并[1,2-b][1,2,4]三嗪-7-基]联苯基-2-甲腈(TPA023B)或其盐的多晶型物。在一个方面中，本文公开了TPA023B与磷酸的结晶多晶型盐或共晶。在另一个方面中，本文公开了TPA023B与硫酸的结晶多晶型盐或共晶。本文还描述了其制备方法和使用方法。
Bibliography:Application Number: CN202080074393