Synthesis process of 2, 2, 2-trifluoroacetamidine
The invention relates to the technical field of pharmaceutical chemical synthesis, in particular to a synthesis process of 2, 2, 2-trifluoroacetamidine, which specifically comprises the following steps: taking trifluoroacetic anhydride as an initial raw material, amidating with p-methoxybenzylamine...
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Main Authors | , |
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Format | Patent |
Language | Chinese English |
Published |
30.08.2022
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to the technical field of pharmaceutical chemical synthesis, in particular to a synthesis process of 2, 2, 2-trifluoroacetamidine, which specifically comprises the following steps: taking trifluoroacetic anhydride as an initial raw material, amidating with p-methoxybenzylamine to obtain 2, 2, 2-trifluoro-N-(4-methoxybenzyl) acetamide, sulfating to obtain 2, 2, 2-trifluoro-N-(4-methoxybenzyl) thioacetamide, reacting with 4-methoxybenzylamine to obtain 2, 2, 2-trifluoro-N-(4-methoxybenzyl) thioacetamide, and reacting with 4-methoxybenzylamine to obtain 2, 2, 2-trifluoro-N-(4-methoxybenzyl) thioacetamide. The preparation method comprises the following steps: carrying out substitution reaction on 2, 2, 2-trifluoro-N-(4-methoxybenzyl) acetamidine and an aminomethanol solution under the action of silver carbonate to obtain 2, 2, 2-trifluoro-N-(4-methoxybenzyl) acetamidine, and carrying out palladium-carbon high-pressure hydrogenation to remove p-methoxybenzyl to obtain 2, 2, 2-trifluoroacetami |
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Bibliography: | Application Number: CN202210776483 |