Methods of treatment with myosin modulators

• Main Authors: MCDOWELL ROBERT, SEMIGRAN MARTIN J, FERNANDES SHELDON, LAMPLE KEVIN L, SCHUNERT ANDREAS, LI WANYING, MA, GORDON, Y, MILIFF MICHAEL E, SEHL, LOUIS, C, FANG LIANG, ZHANG DANLU, CAIN BRIAN E, HENZE, MICHAEL, P, EDELBERG, JOHN, M, DEL RIO CARLOS L, KARLSSON, TOMAS, NISSEN STEPHAN, OBER, DANIEL, L, DESAI, MOHAN, Y, LAMBIN, JOHN
• Format: Patent
• Language: Chinese; English
• Published: 26.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed herein are methods of treatment comprising administering to a subject in need thereof a therapeutically effective amount of a myosin modulator, or a pharmaceutically acceptable salt thereof, and diagnostic methods that can be used in conjunction with those treatments. Due to the observations exhibited in clinical trials performed in the preclinical environment with Mavaktai as well as with Mavaktai and other myosin inhibitors, there is provided herein a new insight on how advantageously a myosin inhibitor is used to affect the disease state of HCM and other diseases. 本文公开了治疗方法及可结合那些治疗使用的诊断方法，所述治疗方法包括向有需要的受试者施用治疗有效量的肌球蛋白调节剂或其药学上可接受的盐。由于在临床前环境中用玛伐凯泰以及用玛伐凯泰和其他肌球蛋白抑制剂进行的临床试验中展现的观察结果，本文提供了关于如何有利地使用肌球蛋白抑制剂来影响HCM和其他疾病的疾病状态的新见解。